Six sigma dissertation
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Dissertation Proposal – Lean Six Sigma Programmes in - TRAP NCI
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bio graph Leonardo DiCaprio is an award-winning actor and a three-time Academy Award® nominee. DiCaprio#8217;s 5th collaboration with Director Martin Scorsese #8220;The Wolf of six sigma Wall Street#8221; is available on Blu-ray DVD now. DiCaprio starred as Jay Gatsby in “The Great Gatsby”, directed by Baz Luhrmann. Prior to “The Great Gatsby”, he starred in #8220;Django Unchained,#8221; where he received a Golden Globe nomination for his work. As the title role in “J. Edgar”, under the direction of Clint Eastwood, he received Golden Globe, Critics’ Choice and Screen Actors Guild (SAG) Award® nominations for his work in the film.
Additionally, he starred in essay about system, Christopher Nolan’s blockbuster “Inception,” and the dramatic thriller “Shutter Island,” which marked his fourth collaboration with director Martin Scorsese. DiCaprio earned an Oscar® nomination in 2007 for his performance in dissertation, Edward Zwick’s drama “Blood Diamond,” also receiving Golden Globe, Critics’ Choice and Screen Actors Guild (SAG) Award® nominations for literature paper his work in the film. That same year, he garnered Golden Globe, BAFTA Award, Critics’ Choice Award and SAG Award® nominations for his role in the Oscar®-winning Best Picture “The Departed,” directed by Scorsese. He also shared in a SAG Award® nomination for Outstanding Motion Picture Cast Performance as a member of the ensemble cast of “The Departed.” He previously earned an Academy Award® nomination for his performance in Scorsese’s acclaimed 2004 biopic “The Aviator.” DiCaprio’s portrayal of Howard Hughes in that film also brought him a Golden Globe Award for dissertation Best Actor in a Drama, as well as Critics’ Choice and BAFTA Award nominations. He was also honored with two SAG Award® nominations, one for Best Actor and another for essay about childhood memory Outstanding Motion Picture Cast Performance as part of the “The Aviator” cast. In addition to six sigma, his acting work, DiCaprio launched his own production company, Appian Way. College English Paper! Under the Appian Way banner, he wrote, produced and narrated the acclaimed environmentally themed documentary “The 11th Hour.” Among Appian Way’s other productions are the aforementioned “Shutter Island” and “The Aviator,” as well as “The Ides of March,” “Red Riding Hood,” “Orphan,” “Public Enemies” and the soon to be released “Out of the Furnace” starring Christian Bale and six sigma Woody Harrelson and “Runner, Runner” starring Justin Timberlake and Ben Affleck. Born in Hollywood, California, DiCaprio started acting at the age of 14. His breakthrough feature film role came in Michael Caton-Jones’ 1993 screen adaptation of Tobias Wolff’s autobiographical drama “This Boy’s Life.” That same year, he co-starred in Lasse Hallstrom’s “What’s Eating Gilbert Grape,” earning his first Oscar® and Golden Globe nominations for his performance as a mentally handicapped young man. In addition, he won the National Board of Review Award for Best Supporting Actor and essay about childhood the Los Angeles Film Critics Association’s New Generation Award for his work in the film.
In 1995, DiCaprio had starring roles in dissertation, three very different films, beginning with Sam Raimi’s Western, “The Quick and the Dead.” He also garnered praise for his performance as drug addict Jim Carroll in the harrowing drama “The Basketball Diaries,” and for his portrayal of disturbed pansexual poet Arthur Rimbaud in Agnieszka Holland’s “Total Eclipse.” The following year, DiCaprio starred in about our education, Baz Luhrmann’s contemporary screen adaptation of “William Shakespeare’s Romeo + Juliet,” for which he won the Best Actor Award at the Berlin International Film Festival. He also joined an all-star ensemble cast in “Marvin’s Room,” sharing in a SAG Award® nomination for Outstanding Motion Picture Cast Performance. What issue do you care about the dissertation, most? New documentary #8220;Before The Flood#8221; to air globally on of community thesis NatGeo on October 30th. Before the Flood presents a riveting account of the dramatic changes now occurring around the world due to climate change, as well as the actions we as individuals and as a society can take to prevent catastrophic disruption of life on our planet. Leonardo calls for climate action at Mayors summit in Paris. Leonardo addresses Mayors and local leaders gathered in Paris on six sigma the importance of switching to renewable energy to tackle the climate crisis. Eclipse! Leonardo joins artists and public leaders at the Global Citizen Festival. Leonardo joins artists and public figures from dissertation, around the world to celebrate the adoption of the UN Sustainable Development Goals at the 2015 Global Citizen Festival in Central Park, New York. Leonardo Addresses the World Economic Forum in Davos.
In January, Leonardo DiCaprio attended the World Economic Forum in student behaviour, Davos, Switzerland to receive the six sigma dissertation, prestigious Crystal Award. The award is given to artists and cultural leaders who are helping to address the world#8217;s humanitarian and environmental challenges, including climate change. Greek Paper! Leonardo calls for climate action at Mayors summit in six sigma, Paris. Leonardo addresses Mayors and college paper local leaders gathered in Paris on the importance of switching to renewable energy to dissertation, tackle the climate crisis. Leonardo DiCaprio honored with SAG Foundation#8217;s #8216;Actors Inspiration Award#8217; Leonardo DiCaprio received the on problems behaviour, nonprofit Screen Actors Guild Foundation’s single “Actors Inspiration Award” at six sigma dissertation, the SAG Foundation 30th Anniversary Celebration on Thursday, November 5th at the Wallis Annenberg Center for the Performing Arts in Beverly Hills. Leonardo joins artists and greek literature research paper public leaders at the Global Citizen Festival. Six Sigma Dissertation! Leonardo joins artists and public figures from Families, around the world to six sigma, celebrate the adoption of the UN Sustainable Development Goals at the 2015 Global Citizen Festival in essay, Central Park, New York. Leonardo and LDF join more than 400 institutions pledging to six sigma dissertation, divest from fossil fuels. Leonardo and the Leonardo DiCaprio Foundation announced today they are joining over 400 institutions and 2,000 individuals participating in college, the pledge Divest-Invest pledge, along with governments and investors from 43 countries. 2nd Annual LDF Gala raises over dissertation $40 million.
LDF held its annual fundraising gala in thesis, St. Tropez raising more than $40 Million to protect Earth’s last wild places and implement solutions to dissertation, preserve and save the environment. Leonardo#8217;s new film #8216;The Revenant#8217; set in Canadian wilderness. Leonardo DiCaprio will play the role of Hugh Glass in upcoming film The Revenant, shot entirely with natural light in the remote wilderness of Canada. Copyright Greenhour, Inc.
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Dissertation Proposal – Lean Six Sigma Programmes in - TRAP NCI
narrative essay So, your professor just gave you a new assignment, and six sigma dissertation, it looks like an interesting topic. Essay About Childhood Memory! The problem is you don’t know how to write a narrative essay. Relax (but don’t procrastinate)! Narrative essays are actually pretty fun to write. What’s more, they don’t usually require much research since they are typically based on your life experiences. All that said, there are some important rules to follow. This blog post will tell you all about narrative essays and teach you how to write a narrative essay that stands out. Narration is writing that tells a story. Dissertation! A good way to wrap your mind around a narrative is to think about how a narrator in a film presents a scene.
He tells the story from a particular perspective, giving a detailed account of what happened. Consider the narration in this clip from How the Grinch Stole Christmas : So, how is the narrator’s recounting of the Grinch’s failure to steal Christmas related to learning how to write a narrative essay? As the english paper, narrator in your essay, you set the six sigma dissertation, scene and tell the story from Military Deployment and their Families your viewpoint, giving a detailed report of six sigma events. Chances are, you narrate stories every day. Essay! I mean, didn’t you just tell your friend all about that funny thing that happened in six sigma, class earlier? You know how to narrate. So, writing a narrative essay should be easy, right?
Well, hold on, it’s not that simple. Essay With Student! One of the dissertation, challenges with writing narrative essays is that you often have to distill a complex story into a limited (and to-the-point) number of Military and their Families words. Six Sigma Dissertation! At the same time, you have to garner enough interest to keep the reader engaged in your story. Anyone can tell a story, but not everyone can tell a story that captures an eclipse of community audience. It’s important to keep some rules in mind as you learn how to six sigma dissertation, write a narrative essay. The best way to english paper, learn how to write a narrative essay is to see an example.
I’m going to pretend that I’m the character Rudy (from the 1993 film Rudy ), and I’m going to six sigma, write a narrative essay about something that happened in my (Rudy’s) life. First, watch this clip from the of community thesis, film: Now, I will write a sample narrative essay, as if this clip were based on my experience. Just as with a true narrative essay, my memory of the experience may be slightly different than the reality of the experience. You always have some creative license with narrative essays–whether they are fictional or not. Read this sample essay first, and then I’ll break it down into its elements: A janitor changed my life. I was at a low point, ready to quit everything–even when I had it all. I didn’t realize how lucky I was. At 5 foot nothing, 100 and nothing pounds, I was hardly your typical football player.
But, that didn’t stop me from believing that I could play for six sigma dissertation Notre Dame. It turns out, the most important part of achieving my dreams is believing in myself. After two years of essay about trying hard to prove that I was worthy of six sigma dissertation playing, I found out that I hadn’t made the dress list for our kickoff game.After fighting to eclipse of community, be on six sigma the team and sweating through every practice, I was going to sit on the bench…again. So, I decided to call it quits. Who was I to think that I deserved anything better than working at the steel plant, just like my father and Deployment and their, my brothers?
If that life was good enough for them, why wasn’t it good enough for six sigma me? As I stood there in essay student, section five, staring out at the empty stadium, I thought of how proud my dad would have been to see me out there on the field playing for the team we both loved so much. I felt so stupid. I wasn’t a football player. I was a bench warmer… nothing more. That’s when the dissertation, team janitor found me standing there. “Hey,” he said. “Don’t you have to be at practice?” “Not anymore,” I said, annoyed. “I quit.” “Why’d you quit? You don’t seem like the quitting type.” “I don’t know,” I said. Essay! “I just don’t see the point anymore.”
In that moment, the janitor reminded me of six sigma everything I had already achieved. Eclipse! Against all odds, I had stuck with the team for two years, and I was going to graduate with a degree from Notre Dame. What he said next drove his point home. Dissertation! He said, “In this lifetime, you don’t have to prove nothin’ to nobody except yourself.” He had a point. I had already proven myself to about our education, everyone except for dissertation me.
If I didn’t believe in myself… who would ever believe in about, me? Thanks to the janitor’s wisdom, I eventually played my first–and only–game that season, and I proved to myself that I can achieve anything I set my mind to. Okay, now let’s pick this thing apart. Six Sigma Dissertation! In the following section, I’ve highlighted certain concepts from my sample narrative essay in different colors. Their explanations follow. A janitor changed my life. I was at a low point, ready to quit everything–even when I had it all. I didn’t realize how lucky I was. At 5 foot nothing, 100 and essay, nothing pounds, I was hardly your typical football player. But, that didn’t stop me from believing that I could play for Notre Dame. It turns out, the six sigma dissertation, most important part of achieving my dreams is believing in myself.
Let’s break it down. Start with a strong hook . Just as with any other form of writing, your first paragraph should start with a strong hook. The sentence, “ a janitor changed my life ,” sets up the story with a bold statement meant to capture the attention of my readers. The goal is to make readers ask, “How did a janitor change your life? What happened?”For more information on hook sentences, read my blog post, “How to Write Good HookSentences.” Set the scene . In this section of literature paper my first paragraph, I set the scene.
I give the reader some context for my story (I was at a low point. I was a struggling football player for Notre Dame… etc.). Define the dissertation, purpose . Have you ever heard anyone talk on and on about something without making a point? This is a common trap for writers attempting a narrative essay. A good narrative essay has a purpose: perhaps you learned a hard lesson, or perhaps you transformed into a more mature person. Essay About System! Whatever the case, that purpose should be stated in the first paragraph.
In the example narrative, my purpose is to make the point that “ the most important part of achieving my dreams is dissertation, believing in myself .” As you can see, the first paragraph is critical to setting up a good story. Now, let’s talk about what goes on in your body paragraphs. After two years of trying hard to prove that I was worthy of playing, I found out that I hadn’t made the dress list for our kickoff game. Of Community! After fighting to be on the team and sweating through every practice , I was going to sit on the bench…again. Dissertation! So, I decided to call it quits. Who was I to think that I deserved anything better than working at the steel plant, just like my father and my brothers? If that life was good enough for about them, why wasn’t it good enough for me? As I stood there in section five, staring out at six sigma dissertation, the empty stadium , I thought of how proud my dad would have been to see me out about there on dissertation the field playing for the team we both loved so much. I felt so stupid.
I wasn’t a football player. I was a bench warmer… nothing more. That’s when the childhood memory, team janitor found me standing there. “Hey,” he said. “Don’t you have to be at practice?” “Not anymore,” I said, annoyed . “I quit.” “Why’d you quit? You don’t seem like the quitting type.” “I don’t know,” I said. Six Sigma! “I just don’t see the essay childhood, point anymore .” In that moment, the janitor reminded me of everything I had already achieved. Dissertation! Against all odds, I had stuck with the team for english paper two years, and I was going to graduate with a degree from Notre Dame.
What he said next drove his point home. He said, “In this lifetime, you don’t have to six sigma dissertation, prove nothin’ to nobody except yourself.” Let’s break it down. Use vivid and appropriate detail . The goal here is to english, recreate the story for your reader just like it happened. Make the story vivid and full of detail. Note, however, that this is not a descriptive essay, so only dissertation, include the details that matter most to your story . Use dialogue . Greek Literature Research! Sometimes, a great story can’t be told without dialogue. It’s definitely okay to six sigma dissertation, incorporate dialogue, as necessary, especially if it’s a natural part of greek your story.In my sample essay, the six sigma, conversation with the essay with behaviour, janitor is critical to six sigma, the story, so including the dialogue from this interaction is appropriate. English Paper! Write chronologically . Dissertation! It’s a smart idea to write in chronological order, especially if you are an inexperienced writer. Essay Memory! What happened first, next, and last?This will help you to stay true to your story and not wander.
In this sample, I focus on the sequence of events that led me to six sigma, my moment of truth, how the janitor talked me into staying on the team, and how this changed my perspective on essay about life. Maintain consistency in narration . Dissertation! In this example narrative essay, I chose to write in of community, the first-person narrative voice and in the past tense.I chose first person because I was telling a story that happened to me (remember, I’m pretending to be Rudy in this sample). Six Sigma Dissertation! I chose past tense because I’m telling a story that happened in research paper, the past .Chances are, you’ll want to write your narrative essay in first person, past tense, too. In some cases, you may find that writing in third person is a better choice–especially if you are recounting a story that happened to dissertation, someone else. But, whatever you choose, keep it consistent throughout.
Okay! Let’s move on to the last paragraph. He had a point. I had already proven myself to everyone except for me. If I didn’t believe in myself… who would ever believe in me? Thanks to the janitor’s wisdom, I eventually played my first–and only–game that season, and I proved to myself that I can achieve anything I set my mind to thesis, . Let’s break it down. Restate your purpose . Dissertation! In your final paragraph, leave your reader with a clear restatement of your purpose.Remember, I began this sample narrative essay by stating my purpose: “The most important part of achieving my dreams is believing in myself.” In the final paragraph, I closed with a restatement of this same point: “ I proved to myself that I can achieve anything I set my mind to. ” Here are the eight concepts we just covered, distilled into on problems with behaviour, handy table form for your convenience.
Final Thoughts on How to six sigma dissertation, Write a Narrative Essay. As you set out to write your narrative essay, bring the readers on your journey with you. Eclipse Thesis! Give them a reason to listen to dissertation, your story. If you’re uncertain what to about childhood, write about, remember that a good personal narrative essay will show some sort of transformation. For example, you started out as a shy person, but had an interesting experience that made you more outgoing. Find a story of transformation, and then write about what happened. If you need more ideas, check out these example narrative essays. Finally, always be sure to edit your personal narrative essay before you submit it!
It doesn’t matter how awesome your story is six sigma dissertation, if the narrative is essay behaviour, masked by six sigma, bad grammar or sentence structure errors. Psst. 98% of Kibin users report better grades! Get inspiration from over 500,000 example essays. About the essay about childhood, Author. Naomi Tepper is a former Kibin editor, the dissertation, former content manager for the Kibin blog, and with student behaviour, forever a word nerd. Wooooow, thnx this really saved my day cause I had no idea of how to write a narrative essay. Happy to help and thanks for reading! You’re welcome!
Thanks for reading. Hey… anyone wants to six sigma dissertation, learn the best way to write an our education system essay without tutoring…. here it it. Six Sigma Dissertation! this stuff is as good as perfect to learn an essay. +Naomi Tepper thanks a ton.. Essay About Childhood Memory! this will help me improve my narrative writing skills.. Thanks again #128578; Aww, shucks thank you!
More than happy to help. Thank you I really appreciate your help. n if you don’t mind, is it possible that you could help me out with a few links or something, so i could improve my writing skills. (other types of dissertation writings as well- like argumentative, descriptive, persuasive, summary writing)… oh! n am also having my IGCSE pre-boards coming up this Monday so even a few tips would also help. Literature Research Paper! Thanks:) Truthfully, I don’t know much about the IGCSE boards, but I imagine there might be some timed writing tests involved, in six sigma, which case this post might come in handy: https://www.kibin.com/essay-writing-blog/how-to-write-a-timed-essay/ Thanks alot… all of them are really helpful #128578; Can you please guide me to another link with summary writing.. i think the above link doesn’t seem to be working.. Thanks in advance. #128578; Hi Naomi. Found this really helpful, thank you. Greek Paper! I was wondering if you have any additional advice that would help me hone my writing skills. #128578;
Hi again, Sowmya! Woot! Looks like your finding your way around our blog. Nice to see you reading this post as well. Yes, I have lots of advice on writing better essays. Check out the comment I left for Joshua (below), it links to some of my most useful blog posts. Is it possible if you could share a link on summary writing to me, it would be of dissertation great help.
Thanks in advance. thank for english the awesome help. You are so welcome! Thanks for the comment. #128578; THANK YOU SO MUCH . YOU HELPED ME A LOT ! Awesome! Happy to help. #128578; I want to six sigma dissertation, help my son write a narrative. He has to choose to be something from our timeline of study with our coop. He has chosen the Black Death.
This seems so exciting to me but I simply cannot wrap my head around how to approach this as a narrative. He actually wants to about childhood memory, BE the black death. Ideas? Wow! Your son sounds very creative. I love this concept.
Your son should choose the six sigma, characteristics of the Black Death that he wants to personify. Before writing, answer some questions: What’s his motive (as the Black Death)? How does he feel about the essay with student, “work” he is doing? Does he have a visible form or is dissertation, he invisible? If visible, how do humans see him? Try to keep the personification consistent throughout. Then build a narrative arc around this “character” with a beginning, middle and end.
Perhaps tell the story of essay visiting on a particular family. What does he learn from the experience? What is the point (thesis)? Most importantly have fun! I love this! Do you have an six sigma example with a guide just like the one you did for Deployment Families narrative essay but for an illustration essay? Thanks so much Erin! Sorry to ask again, but do you have examples for a research essay and another narrative without dialogue?
I want to be able to dissertation, show my college students different examples of Military narrative essays.
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8 Business Analyst Resume Secrets You Need to six sigma dissertation Know (Especially If Don#8217;t Have the BA Job Title) Are you looking to get your business analyst resume into the #8220;yes#8221; pile when you apply to essay our education a business analyst job? Are you wondering how you can showcase your business analysis experience and qualifications when you#8217;ve never held the job title of business analyst? Would you like to know some honest ways to dissertation construct an effective business analyst resume that do not involve gimmicks and trickery? In this article, we#8217;ll cover the and their, 8 secrets you need to know so that you hear back from more business analyst job applications. They#8217;ll help you showcase your business analyst qualifications, even if you#8217;ve never held the job title of dissertation #8220;business analyst.#8221; Before I forget, I want to be sure you know about my step-by-step BA career planning course (it’s free) that’s designed to help you, the essay about, mid-career professional, kick-start your business analysis career. Now, onto six sigma the 8 secrets.
1 Your Business Analyst Resume Does Not Need to Catalog Your Work History. Deployment And Their. Many professionals fall into the trap of dissertation thinking they need to include a complete catalog of their work experiences and skills in college english, their resume. The first secret you need to be #8220;in#8221; on when putting together your resume is that your resume is dissertation, not a catalog, it#8217;s a sales document. This means you can be selectively honest about the skills and experience you include and eclipse, emphasize in your resume, and you should organize your resume so that it presents your qualifications in the best possible way. Provided you are applying to six sigma dissertation business analyst jobs you are reasonably well qualified for, something we talk about in our business analyst job search process, the next 7 secrets will help you create a resume that sells your qualifications in a way that doesn#8217;t make you uncomfortable. 2. Create a Specific Summary So Your Resume Isn#8217;t Quickly Sent to the #8220;No#8221; Pile. Because most recruiters scan your resume instead of read it, there are a few elements of greek research your resume that will get you the most attention. The first one of these is your objective or summary statement.
While it may seem that being vague or general will open up more possibilities, the six sigma dissertation, reality is just the opposite . Highlight your business analysis accomplishments and make it crystal clear that you are qualified for the types of BA jobs to which you are applying. Deployment Families. Because many recruiters skip right past the objective on your resume, you need to make sure that other parts of your resume draw them in too. Let#8217;s move on to those other parts. Six Sigma Dissertation. 3. Tweak Your Job Titles to college english paper Get Your Resume Read. If the six sigma, recruiter skims right past your objective and accomplishments section, their eyes are going to rest on greek literature, the most recent job titles you’ve held . These are typically in bold (if not, they probably should be) and stand out. Do your job titles present you as a candidate that is qualified for the types of jobs to which you are applying?
If your most recent job title is six sigma dissertation, listed as “Network Engineer,” “Software Developer” or “Customer Support,” you are most likely to get calls for jobs with similar titles. Instead, consider tweaking your job titles to present your recent job roles honestly and accurately. For more on being honestly creative , check out our post, How to Handle Job Titles on a Business Analyst Resume. 4. Highlight Your Most Relevant Skills and Still Be Honest. Remember how we said that your resume is english, a sales document? That means that you have the license to selectively highlight your most relevant skills. One way to do this is to focus on six sigma dissertation, the projects where you held the Military Deployment Families, most BA responsibilities this enables you to get beyond being a #8220;jack of all trades#8221; and focus on your business analysis career experiences. And it does not mean #8220;overselling#8221; yourself it#8217;s just a matter of selectively telling the truth . Dissertation. Out of all the business analyst resumes I review, by and large this is where most professionals need to invest the most time. (By the on problems with student, way, you#8217;ll learn how to get your resume noticed for business analyst jobs in Building a BA Resume that Lands You Interviews a virtual, self-study course that helps you highlight your relevant business analysis experience even if you#8217;ve never held a #8220;business analyst#8221; job.) Here are some of the dissertation, mistakes I see. A software developer talks about the coding language they used, not the business problem they analyzed and eclipse of community thesis, solved.
A customer support person details their primary responsibilities and the “special project” they participated in dissertation, as an SME/BA is relegated to a single bullet point that goes unnoticed. A prior manager is so “accomplishments focused” that they overshadow their abilities to essay about our education system roll up their sleeves and do business analysis work such as role definition, business process analysis, managing change, and obtaining buy-in across multiple departments. Six Sigma. 5. Use Business Analysis Terminology to Demonstrate Your Capabilities. Let me let you in on another secret. About Our Education. As a qualified business analyst job candidate, you know more about business analysis than the six sigma, average recruiter. While you know that #8220;process flows#8221; and eclipse of community thesis, #8220;workflow diagrams#8221; mean the same thing, the person doing the dissertation, first-pass review of your resume might not. This means that you#8217;ll hear back from the most opportunities if you use the behaviour, right terminology to talk about six sigma dissertation your experiences in your resume. These are called transferable business analysis skills. Here#8217;s an example from my own resume: As a QA Engineer I coordinated multiple business groups to essay on problems student review a particular application before it went live to our customers. At the time, we called this activity #8220;data testing.#8221; Later I learned the six sigma dissertation, formal term was #8220;user acceptance testing.#8221; I now use #8220;user acceptance testing#8221; on my resume. It#8217;s accurate and honest and presents me as more qualified for certain business analysis positions.
Once you have selected your most relevant skills and the right terminology for essay them, you#8217;ll want to dissertation craft bullet points that clearly communicate those skills and Deployment and their, build instant credibility. And that leads us to secret #6. 6. Get Instant Credibility by Blending Accomplishments and Responsibilities in Your Bullet Points. Six Sigma. I#8217;m often asked whether to highlight your accomplishments (what you achieved for your project or organization) or your responsibilities (what you did for your organization) in english, your work history section. In the your resume#8217;s bullet points, you want to six sigma show how you used a business analysis skill and achieved something significant by applying that skill. So you essentially back-up an accomplishment with a qualification, using the right terms you#8217;ve selected above. You can add to Military Deployment your credibility by using a variety of concrete details to talk about your contributions. Even if you don#8217;t have access to precise project results, you can include a variety of six sigma dissertation numbers and details that help give shape to your experiences, thereby helping your reader see what kinds of things you might be able to on problems student do for six sigma dissertation their organization. 7. Address Any Employment Gaps Clearly. Some of the resume gurus will tell you to hide an essay, employment gap in your resume by dissertation reorganizing it in a functional resume format.
In all the work I#8217;ve done with new business analysts and transitioning professionals, I#8217;ve never seen this approach work. Assume the person reading your resume is eclipse of community thesis, a relatively intelligent human being who is not going to miss a gap because you#8217;ve reorganized your work history in a confusing way. Assume instead they will doubt your transparency (which just happens to be a key business analyst trait). Giving others the opportunity to dissertation make false assumptions about our education you and your work, will only get your resume into the #8220;no#8221; pile. Proactively address your employment gap on your resume. Tell an honest story that shows you are ready, able, and willing to dissertation do the work of a business analyst. 8. Someone Else Cannot Write Your Resume For You. Creating a resume that clearly showcases your best business analysis qualifications is our education, not easy work.
If your written language skills are lacking, hiring a resume writer could help you craft bullet points that honestly communicate your qualifications. Six Sigma. But keep in mind that as a business analyst you will be writing a lot of essay memory documentation, so your resume is an artifact that demonstrates your ability to fulfill a key business analysis competency, just like the business analyst job interview is a time to demonstrate you can ask insightful questions. A resume writer may or may not have a deep understanding of the business analysis profession. They can hone and tweak your resume, but you need to own your business analysis qualifications and give them a significant amount of six sigma content to work with. Yes, I know it’s painful to, yet again, update your resume. But if you aren’t getting calls for the right type of jobs, then this is exactly where your job search time will be best spent. Essay About Childhood. (Getting your resume right will also help you prepare for the job interviews that come for it, so that#8217;s an added bonus.) And if you’d like my help creating a resume to six sigma dissertation showcase your business analyst qualifications, check out Building a BA Resume that Lands You Interviews. In this virtual, self-study course, you#8217;ll learn my step-by-step process to creating a resume that gets beyond tricks and gimmicks by applying tested patterns to draw out your business analyst qualifications and of community thesis, catch the dissertation, attention of potential interviewers. Stay informed about college english paper new articles and six sigma, course offerings. With. (You'll get a free step-by-step BA career planning course too). your details are safe with us. Step-By-Step BA Career Planning Course New Articles to Help You Succeed as a Business Analyst Information on New Course Sessions, Books, and Work Aids.
***Business Analyst Webinars (Complimentary)*** What Experience #8220;Counts#8221; as Business Analyst Experience? (5 Examples) Being a BA is Not for the Faint of Heart. Six Sigma Dissertation. How Do I Convince My Team to Adopt Better Requirements Practices? Why This Might Be Taking Longer Than You Expect. Use Cases: A Personal History (and a bit of a love affair) What To Do When a Developer Says #8220;That#8217;s Impossible#8221; No content on this site may be reused in college english paper, any fashion without permission from Laura Brandenburg.
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Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models. © BioMed Central Ltd 2011. Published: 30 September 2011. Systemic lupus erythematosus (SLE) is a complex disease characterized by the appearance of autoantibodies against nuclear antigens and the involvement of multiple organ systems, including the kidneys. The precise immunological events that trigger the onset of clinical manifestations of SLE are not yet well understood. However, research using various mouse strains of six sigma dissertation spontaneous and inducible lupus in greek literature research paper the last two decades has provided insights into six sigma dissertation, the role of the immune system in the pathogenesis of this disease. According to our present understanding, the with student behaviour immunological defects resulting in the development of SLE can be categorized into two phases: (a) systemic autoimmunity resulting in increased serum antinuclear and antiglomerular autoantibodies and (b) immunological events that occur within the target organ and result in end organ damage. Aberrations in the innate as well as adaptive arms of the immune system both play an six sigma important role in the genesis and progression of lupus. Here, we will review the essay about childhood present understanding - as garnered from dissertation studying mouse models - about the roles of various immune cells in lupus pathogenesis. Pathogenic mechanisms of systemic lupus . Different subpopulations of immune cells interplay to directly or indirectly regulate other subpopulations by releasing different cytokines and other mediators of inflammation, thereby contributing to the progression of the systemic disease. Student. The hyperactivated leukocytes as well as the dissertation pathogenic autoantibodies and essay about our education immune complexes resulting from the systemic disease ultimately play an important role in local autoimmunity and end organ disease within target organs like the kidneys.
Ab, antibody; BAFF, B-cell activation factor; DC, dendritic cell; IC, immune complex; IFN-I, interferon-I; IL-10, interleukin-10; M?, macrophage; MHC, major histocompatibility complex; self-Ag, self-antigen; TCR, T-cell receptor; TGF-?, transforming growth factor-beta. Systemic autoimmunity in dissertation systemic lupus erythematosus: handling of self-antigens. The presence of eclipse of community high titers of six sigma autoantibodies against nuclear antigens is the essay childhood hallmark of SLE. Six Sigma Dissertation. Whereas there is little evidence to indicate whether self-antigens in SLE are aberrant in sequence or structure, there is evidence that the aberrant handling of self-antigens could facilitate lupus pathogenesis. Although apoptotic bodies are normally rapidly cleared with the help of the complement and other systems, defects in this clearance system could lead to of community thesis the accumulation of apoptotic bodies and six sigma dissertation their prevalence in serum [ 1 ]. Essay. There have been limited reports that NZB/W F1 and MRL/lpr mice, which spontaneously develop a lupus-like disease, have high serum levels of nucleosomes [ 2 , 3 ]. Dissertation. Non-autoimmune C3H, BALB/c, and C57BL/6 mouse strains, when injected with apoptotic bodies, developed serum autoantibodies similar to those seen in SLE [ 4 ]. Although these studies warrant independent confirmation, they support the paper notion that apoptotic cells could harbor the immunogens responsible for antinuclear antibody formation. Moreover, mice with defects in genes that play an important role in the clearance of dissertation apoptotic bodies, like DNase I, serum amyloid protein P (SAP), sIgM, or tyrosine kinase c-mer, all develop SLE-like disease with elevated levels of antinuclear antibodies [ 5 – 8 ]. These data support the hypothesis that the inefficient clearance of apoptotic bodies could be one factor leading to the development of SLE. The important role of the behaviour complement system and FcR in the process of clearing apoptotic materials has also been recently documented. Thus, C1q-deficient mice exhibit impaired internalization of apoptotic cells by peritoneal macrophages and develop proliferative glomerulonephritis characterized by high levels of apoptotic cell bodies [ 9 ]. Cells of the adaptive immune system as mediators of systemic autoimmunity in six sigma dissertation systemic lupus erythematosus. B lymphocytes in systemic lupus erythematosus. Autoantibodies are major contributors to end organ damage as illustrated by the glomerulonephritis associated with antinuclear and anti-glomerular antibodies, congenital heart block associated with anti-Ro antibody, and thrombosis associated with anti-cardiolipin antibodies [ 10 ]. About. However, B cells can contribute to dissertation SLE pathogenesis through additional pathways.
For example, lupus-prone MRL/lpr mice that are made B cell-deficient exhibit a markedly attenuated disease. These mice have an absence of autoantibodies, as expected, but also display a dramatic lack in about memory T-cell activation. This study, by Shlomchik and dissertation colleagues [ 11 ], implied an essential role for B cells, but not necessarily autoantibodies, in about the pathogenesis of lupus [ 11 ]. Six Sigma Dissertation. In another study, Shlomchik and colleagues [ 12 ] used MRL/lpr mice expressing a mutant immunoglobulin (Ig) that cannot be secreted, thus essentially prohibiting autoantibody generation, and showed that those mice still developed nephritis and vasculitis with associated T-cell activation. That study convincingly showed that B cells may contribute to essay on problems with student the development of lupus in ways that are independent of six sigma autoantibodies. The additional role of B cells as antigen-presenting cells that mediate T-cell activation in lupus comes from essay MRL/lpr mice studies showing that B-cell deficiency leads to reduced CD4 + and CD8 + T-cell activation [ 13 ].
Besides secreting proinflammatory cytokines like interleukin-6 (IL-6) and interferon-gamma (IFN-?), B cells may secrete IL-10, which has an anti-inflammatory function. Therefore, B cells that secrete IL-10 (or B10 cells) have been called regulatory B cells and were first reported in B10.PL mice in six sigma dissertation which IL-10-producing B cells were found to essay on problems regulate the six sigma severity of experimental auto-immune encephalitis [ 14 ]. In murine lupus, IL-10 deficiency was found to contribute to more severe disease with an increase in Th1 cytokine levels [ 15 ]. A recent study using CD19 -/- NZB/W mice reported that B10 cells could induce expansion of eclipse regulatory T cells, a subset of T cells with immunosuppressive function [ 16 ]. Six Sigma. However, data from human lupus reveal a different facet of essay about our education system IL-10. In the dissertation case of of community thesis human SLE, studies suggest that IL-10 promotes rather than inhibits lupus [ 17 ]. A better understanding of the role of IL-10-producing B cells and the mechanism of action of IL-10 is required to explain the differences between the murine and human data. Mouse models have helped delineate the molecular mechanisms through which self- reactive B cells might arise. Sle1 is a lupus susceptibility locus derived from the NZM2410 mouse strain. Using Sle1 congenic C57Bl6 mice, Kumar and colleagues [ 18 ] reported that the dissertation auto-immune-associated variant of the Ly108 gene, a member of the SLAM family of immune cell receptors which lies within the Sle1 locus, leads to college loss of B-cell tolerance because of impaired negative selection of six sigma dissertation autoreactive B cells at the immature B-cell stage. On the other hand, increased B-cell signaling, especially in the case of mature peripheral B cells, has been implicated in about childhood memory the pathogenesis of humoral autoimmunity.
Mice that are deficient in various inhibitory molecules that dampen B-cell receptor (BCR) signaling, such as SHP-1 [ 19 ], Lyn [ 20 ], or Fc?RIIb [ 21 ], develop systemic autoimmunity. Mice over-expressing molecules that strengthen BCR signaling, such as CD19, also develop autoimmunity [ 22 ]. Recent studies have implicated a class of immune system receptors called Toll-like receptors (TLRs) in the synergistic activation of B cells by six sigma dissertation, BCR and TLR signaling. Simultaneous engagement of BCRs that are specific for DNA by greek paper, nuclear antigens that are abundant in apoptotic material and TLR9 on six sigma dissertation B cells causes activation of both BCR and TLR signaling pathways [ 23 ]. In the essay student NZB/W and MRL/lpr mouse models of lupus, activation of TLR9 with a synthetic DNA ligand causes accelerated nephritis with increased anti-DNA antibody levels [ 24 ]. On the other hand, TLR9-deficient autoimmune mouse models exhibit lower levels of anti-double-stranded DNA (anti-dsDNA) and anti-chromatin antibody [ 25 ]. Similarly, B cells possessing BCRs specific for RNA could be synergistically activated by BCR and TLR7 signaling [ 26 ]. These findings were supported by research in six sigma the BXSB mouse model of lupus. Duplication of the TLR7 gene in the Yaa lupus susceptibility locus leads to english paper increased gene dosage effects that contribute to the lupus-like phenotype seen in this model [ 27 ]. Defects that may lead to increased survival of autoreactive B cells have also been found to contribute to the development of autoimmunity.
B-cell activation factor (BAFF) is dissertation, a major B-cell survival factor that functions particularly at the transitional B-cell stage. Essay Memory. BAFF transgenic mice develop a lupus-like disease with expansion of the dissertation peripheral B-cell pool and heightened production of autoantibodies [ 28 ]. Increased BAFF levels are thought to infringe the negative selection checkpoint at greek, the T1 transitional stage, thereby allowing the survival and dissertation maturation of autoreactive B cells in english paper the periphery and their participation in the germinal center reaction. These findings are supported by six sigma, the observations that lupus-prone mice exhibit elevated serum BAFF levels and that administration of TACI-Ig, which acts as a soluble receptor for Military and their, BAFF, is effective in treating murine lupus [ 29 ]. T lymphocytes in systemic lupus erythematosus. The obligatory role of T cells in lupus pathogenesis has been demonstrated by using several genetically engineered mouse models [ 30 ]. Lupus T cells are likely to contribute to disease through contact-dependent mechanisms (mediated by CD40L:CD40, OX40L:OX40, and so on) as well as released cytokines [ 30 ]. One important cytokine secreted by the Th1 cells is six sigma dissertation, IFN-?, which plays a pivotal role in literature the production of pathogenic isotypes of antinuclear autoantibodies in murine lupus models. Six Sigma Dissertation. Expression of IFN-? in the skin of transgenic mice leads to the production of anti-DNA and anti-Sm auto-antibodies [ 31 ]. A deficiency of IFN-? in MRL/lpr and about childhood memory NZB/W lupus-prone mice leads to six sigma reduced anti-DNA antibody levels [ 32 , 33 ]. In support of these findings, blocking the IFN-? receptor with monoclonal antibodies or soluble IFN-? receptor reduces disease activity in eclipse lupus-prone mice [ 34 , 35 ]. CD4 + T h17 cells are a recently described CD4 + T-cell subset that appears to mediate pathogenesis in some lupus mouse models [ 36 ]. However, it has become clear that the dissertation contribution of Th17 cells to autoimmunity is Military Deployment Families, far more complex, depending on the disease and mouse model [ 37 ]. Studies in patients with SLE or related diseases have demonstrated that Th17 cells may have a role in disease development in six sigma some, but not all, patients [ 38 ]. Given the heterogeneity of the essay behaviour disease, it may be possible that Th17 cells play a role in lupus pathogenesis in a genetically defined subset of subjects or in particular end organ manifestations and that anti-IL -17 therapy may be helpful specifically in those patients. In addition, the six sigma regulatory T cell subset appears to Military modulate the breakdown of T-cell tolerance in lupus [ 39 ]. Clearly, we need to gain a better understanding of how pathogenic T cells (Th17 cells) and dissertation regulatory T cells, perhaps in literature paper yinyang fashion, dictate disease activity in dissertation lupus. Innate immune cells as mediators of systemic autoimmunity in systemic lupus erythematosus. The important role of the Military innate immune system in six sigma dissertation SLE pathogenesis has only recently been appreciated.
Described below are the possible roles played by three key cell types in the innate immune system. Monocytes/macrophages from patients with lupus have been found to have a reduced capacity to phagocytose apoptotic materials [ 40 ], and their numbers were reduced in the inflammatory exudates from literature research patients with SLE [ 41 ]. Six Sigma Dissertation. It was postulated, on the basis of essay with those studies, that the defective phagocytosis of monocytes/macrophages contributed to inefficient clearing of six sigma dissertation apoptotic materials, leading to autoimmunity [ 42 ], a notion that is supported by mice lacking the myeloid cell receptors, Tyro3, Axl, and Mer receptor tyrosine kinases [ 43 , 44 ]. Whereas c-mer knockout mice exhibited increased anti-dsDNA autoantibody levels without any significant renal pathology [ 43 ], Tyro3/Axl/Mer triple-knockout mice exhibited high levels of on problems student autoantibodies along with multiple end organ involvement [ 44 ]. Monocytes/macrophages can contribute to disease in six sigma dissertation another important way: through the elaboration of college paper proinflammatory cytokines and chemokines. Dissertation. This is illustrated by macrophages from B6. Sle3 congenic mice, in which Sle3 is a lupus susceptibility locus derived from the NZM2410 lupus-prone strain [ 45 ]. These murine studies showed that monocytes/macrophages in lupus probably have defects beyond abnormal phagocytosis and that these cells may take part in aberrant regulation of the immune system. A study by Kilmon and about childhood memory colleagues [ 46 ] demonstrated that macrophages regulate B-cell tolerance by secreting regulatory factors like IL-6 and dissertation CD40L and that macrophages from lupus-prone MRL/lpr mice are less capable of repressing Ig secretion coincident with reduced secretion of these repressive factors.
Collectively, these findings implicate a more significant role for monocytes/macrophages in the pathogenesis of lupus, but further studies in student behaviour patients with SLE are necessary to substantiate these findings. Polymorphonuclear cells in six sigma systemic lupus erythematosus. A neutrophil-specific gene expression signature was reported to correlate positively with SLE disease activity in patients with SLE [ 47 ], suggesting that these cells may play an important role in SLE pathogenesis. Our Education. The exact mechanism by dissertation, which this occurs is on problems with student behaviour, not yet clear. However, a recent study demonstrated that neutrophil extracellular traps, which are networks of DNA, histones, and six sigma neutrophil proteins that function primarily to eclipse thesis trap microorganisms, may be involved in SLE pathogenesis, possibly by generating autoantigens and serving as adjuvants [ 48 ]. The role of neutrophils in murine lupus, unlike that in human lupus, is poorly studied.
Dendritic cells in systemic lupus erythematosus. Studies in six sigma dissertation mouse models have been pivotal in determining the role that dendritic cells (DCs) play in the pathogenesis of lupus. One of the earliest findings implicating the putative role of DCs in eclipse of community thesis the breakdown of tolerance was that transferring DCs from normal donor mice to normal recipient mice could cause loss of dissertation tolerance in the host, leading to the appearance of anti-DNA and anticardiolipin autoantibodies [ 49 ]. College. A study by Chen and six sigma dissertation colleagues [ 50 ] showed that mice with defective DC apoptosis accumulated large numbers of DCs and exhibited chronic lymphocyte activation and systemic autoimmunity. Other studies using murine models have helped in essay about our education identifying the genetic loci responsible for imparting the six sigma dissertation abnormal phenotypes seen in about our education DCs from lupus-prone mice. One such locus is Sle3 , which is a lupus susceptibility locus derived from the dissertation NZM2410 strain of lupus-prone mice. C57BL/6 (B6) mice congenic for greek paper, Sle3 develop moderate glomerulonephritis along with modest levels of antinuclear antibodies [ 51 ]. Moreover, the DCs from dissertation B6.
Sle3 congenics are less susceptible to apoptosis, have a more mature phenotype, and are more proinflammatory. English. They are also more efficient in stimulating T cells in dissertation vitro and eliciting autoantibodies in Military Deployment Families vivo compared with DCs from normal B6 mice [ 45 ]. These studies provided insights into six sigma dissertation, genetic factors and immune mechanisms related to abnormal DC activation in murine lupus. Studies have also shown that DCs play an important role in SLE pathogenesis by secreting potent proinflammatory cytokines, such as type I IFNs (IFN-?) [ 52 ]. Immune complexes (ICs) purified from greek research paper sera of patients with SLE were found to stimulate plasmacytoid DCs (pDCs) to produce IFN-? [ 53 ]. Later studies revealed a possible role of six sigma TLRs as potent inducers of IFN-? production by activated pDCs in lupus. IFN-? secreted by system, activated pDCs was found to directly influence B cells to produce antibodies of the IgG subclass against dissertation, soluble autoantigens in mice [ 54 ]. Essay System. This cytokine also upregulated BAFF expression by monocytes and six sigma mature DCs, which promotes both the survival of college english paper autoreactive B cells and their differentiation into plasmablasts [ 55 ]. Together, these reciprocal events lead to a pathogenic cycle, in which both the innate and adaptive immune systems cooperate and feedback upon each other, eventually leading to high titers of six sigma autoantibodies. Local autoimmunity in essay on problems student behaviour systemic lupus erythematosus. SLE is an autoimmune disease that affects multiple organ systems, including the kidney, skin, heart, lung, and hematopoietic and six sigma dissertation nervous systems. As reviewed below and illustrated in Figure 1 , the players mediating local autoimmunity and renal disease in lupus can be classified broadly as (a) ICs and infiltrating cells of hematological origin and (b) resident cells of the kidneys. Role of immune complexes and of community thesis infiltrating cells of hematological origin in six sigma dissertation lupus nephritis. Anti-DNA and essay childhood DNA ICs were the first ICs isolated from kidney elutes of patients with SLE and six sigma dissertation mouse models [ 56 ]. Intraperitoneal injection of human and murine anti-DNA antibodies was found to trigger lupuslike kidney disease [ 57 ], establishing a direct role of these antibodies in the pathogenesis of lupus nephritis. Similarly, transgenic overexpression of Ig anti-DNA antibodies in mouse models can lead to renal pathology similar to that seen in eclipse thesis human lupus nephritis, highlighting a causal role for six sigma dissertation, autoantibodies in the development of lupus nephritis [ 58 ]. Various mechanisms have been proposed to explain how anti-DNA antibodies may lead to renal disease in lupus [ 59 ]. Anti-DNA antibodies can form ICs with DNA/nucleosomes released from apoptotic cells.
Eventually, ICs become deposited in the kidney, leading to the initiation of a local inflammatory response through Fc?R-or complement-mediated mechanisms or both. Alternately, anti-DNA antibodies may bind to DNA/nucleosomes that have been trapped or 'planted' in the kidney glomerulus. A third mechanism suggests possible cross-reactivity between anti-DNA antibodies and local renal antigens like laminin, alpha-actinin, and heparan sulfate [ 60 ]. Other studies have shown that anti-DNA antibodies are not an absolute requirement for development of SLE. Our Education System. NZM2328.Lc4 mice exhibit lupus-like disease with glomerular IC deposits and eventually develop fatal lupus nephritis.
These mice exhibit no anti-DNA antibody in their serum or in kidney eluates, demonstrating that anti-DNA antibodies are not essential for the development of lupus nephritis [ 61 ]. Antibodies obtained from the six sigma kidney elutes of these mice reacted with various renal antigens, but none was specific for dsDNA [ 62 ]. Another study eluted Igs from renal tissues obtained from of community patients with lupus at dissertation, autopsy and screened the Igs against a panel of 14 different antigens, which included dsDNA, chromatin, Sm, SSA, SSB, and histones [ 63 ]. These authors found that only 0.3% to 41.3% of literature paper total kidney-eluted IgG reacted with these antigens. Therefore, a vast majority of renal antibodies bind to yet-unknown antigens. In support of this idea, a study using a glomerular proteome array showed that serum from lupus mice and patients reacts with multiple nuclear and dissertation matrix-derived autoantigens [ 64 ]. Role of lymphoid cells in lupus nephritis. Lymphoid aggregates with T cells and B cells have been observed within the our education kidneys afflicted by lupus nephritis, although their intrarenal roles remain to be fully appreciated. T cells also play a major role in six sigma dissertation pathogenesis of SLE. Using MRL/lpr mice, Chan and colleagues [ 12 ] showed that mice lacking secreted Ig, but having B cells with a transgenic BCR, still exhibit renal disease. In another study, Schiffer and colleagues [ 65 ] treated NZB/W F1 mice that had established nephritis with CTLA4Ig; this led to disease remission with a significant delay in mortality. Using a transgenic mouse model system, Heymann and colleagues [ 66 ] demonstrated that both cytotoxic T (Tc) cells and Th cells have direct roles in glomerulonephritis. About Our Education. The authors used transgenic mice expressing the model antigens ovalbumin and six sigma hen egg lysozyme in on problems with student behaviour glomerular epithelial cells called podocytes.
Co-injection of ovalbumin-specific transgenic CD8 + Tc and six sigma dissertation CD4 + Th cells into these mice resulted in periglomerular mononuclear infiltrates and inflammation of parietal epithelial cells, similar to lesions frequently observed in human chronic glomerulonephritis. The ovalbumin-specific CD8 + Tc cells were found to be activated and expanded in the renal lymph nodes, and the activation of T cells in turn could be prevented by depletion of DCs. Crosstalk between tubulointerstitial DCs and Th cells resulted in Military Deployment intrarenal cytokine and chemokine production and in six sigma recruitment of behaviour more Tc cells, monocyte-derived DCs, and macrophages. That study was the first direct evidence that glomerular antigen-specific Tc and Th cells can induce glomerulonephritis in a process regulated by DCs. Although similar studies in the context of lupus nephritis are eagerly awaited, the above studies suggest that type IV hypersensitivity-driven mechanisms are likely to be important in mediating autoimmune nephritis. Kidneys of nephritic NZM2328 mice show high levels of expression of Th1-type cytokines like IFN-? and six sigma IL-12 [ 67 ]. Administration of IFN-?, a Th1 cytokine, to NZB/W F1 mice exacerbates disease, whereas the deficiency of IFN-? in MRL/lpr mice ameliorates nephritis [ 32 , 34 ]. Similarly, inhibition of Military IL-18, a cytokine that induces IFN-? and other Th1 cytokines, was found to six sigma dissertation cause a significant reduction in lymphoproliferation and IFN-? production and resulted in behaviour a decrease in lupus nephritis [ 68 ]. Six Sigma. These studies reinforce the concept that type IV hypersensitivity reactions may also contribute to lupus nephritis. Other studies have shown a possible role for IL-4, a Th2-type cytokine, in glomerulosclerosis in essay about childhood which transgenic overexpression of IL-4 was found to dissertation facilitate glomerulosclerosis [ 69 ]. In various studies, IL-4 was found to have a direct effect on fibroblast proliferation, collagen gene expression, and Deployment and their collagen synthesis [ 70 ]. Moreover, inhibition of IL-4 signaling in various lupus-prone mouse models was found to dissertation protect mice from developing advanced nephritis in the presence of anti-DNA antibody and infiltrating inflammatory cells [ 32 ]. Therefore, IL-4 appears to essay about system play a pivotal role in the pathogenesis of dissertation glomerulosclerosis and chronic renal fibrosis in lupus by acting directly upon resident renal cells. Role of eclipse of community thesis myeloid cells in lupus nephritis. Infiltration of DCs in the glomeruli and tubulointerstitial spaces of the six sigma kidneys has been reported in literature research various murine models of six sigma nephritis, including NZB/W F1 [ 67 ], anti-glomerular basement membrane (anti-GBM) [ 71 ], and mice engineered to express a foreign antigen on about memory podocytes [ 66 ]. DCs may promote lupus nephritis by several mechanisms.
One mechanism may be through migration of dissertation DCs to of community thesis local lymph nodes and presentation of renal antigens to autoreactive lymphocytes in six sigma the local lymph nodes, thereby initiating an autoimmune response against renal autoantigens [ 72 ]. Military Families. DCs may also secrete a variety of different proinflammatory and profibrotic cytokines like IL-6, IL-1, IL-18, IFN-?, tumor necrosis factor-alpha (TNF-?), and transforming growth factor-beta to promote renal inflammation and fibrosis [ 73 ]. Despite these possibilities, we do not currently understand the degree to which intrarenal DCs are important for dissertation, lupus pathogenesis or the english paper exact mechanisms through which they operate. Similar to DCs, macrophages are recruited to the nephritic kidneys of patients with SLE and lupus-prone mice [ 74 , 75 ] and influence the progression of dissertation lupus nephritis. In a study using poly(I:C)-induced lupus nephritis in NZB/W mice, proliferative glomerulonephritis was found to be associated with renalinfiltrating macrophages and system renal expression of IFN-inducible genes, matrix metalloproteinases (MMPs), and growth factors [ 76 ]. Glomerular crescent formation and renal MMP and growth factor expression were dependent on renal macrophages that expressed IL-10, MMPs, osteopontin, and dissertation various growth factors, including platelet-derived growth factor-C (PDGF-C) and heparin-binding epidermal growth factor-like growth factor (HB-EGF) [ 76 ]. Student Behaviour. These findings accord a potentially important role for macrophages as mediators of aggressive nephritis in lupus by driving the six sigma expression of various cytokines and growth factors in the kidney. Although macrophage depletion or transfer studies have not been reported in spontaneous lupus nephritis, this role has been examined further in a related murine nephritis model that shares pathogenic pathways with spontaneous lupus nephritis [ 77 ]: anti-GBM-induced nephritis. In the eclipse latter model, depletion and six sigma dissertation adoptive transfer studies have demonstrated a critical role for macrophages in the pathogenesis of nephritis [ 78 , 79 ]. By implanting renal tubular epithelial cells genetically modified to about our education system produce colony-stimulating factor-1 (CSF-1) under the six sigma dissertation renal capsule of MRL/lpr mice, Kelley and colleagues [ 80 ] showed that CSF-1 and TNF-? released by essay about our education system, tubular epithelial cells were responsible for promoting renal pathology by fostering macrophage accumulation. In a study using NZB/W lupus-prone mice, Schiffer and colleagues [ 75 ] identified an activated type II macrophage population as a key marker for proteinuria onset and disease remission and suggested that therapy for six sigma dissertation, lupus nephritis include strategies that prevent both activation of monocytes and their migration to the kidney.
Neutrophils, another myeloid cell subtype, have also been shown to infiltrate nephritic kidneys and contribute to the pathogenesis of experimental nephritis [ 81 ], although their role in lupus nephritis is less well defined. Neutrophils release various proinflammatory cytokines [ 82 ] as well as proteases and reactive oxygen species that lead to acute inflammation and renal tissue injury [ 83 ]. Further studies in murine models are clearly warranted. Role of resident renal cells in about memory lupus nephritis. It is clear that many intrinsic renal cells, including podocytes and tubular epithelial cells, have the capacity to costimulate intrarenal T cells via ICAM-I, MHC-II, B-7, and/or CD40-mediated mechanisms [ 84 – 86 ] or by six sigma dissertation, releasing pathogenic cytokines [ 87 ]. However, the extent to childhood which these intrarenal costimulatory mechanisms and cytokines are operative in spontaneous lupus nephritis remains unknown. On the dissertation other hand, the notion that intrinsic renal cells could be essential in mediating antibody-mediated nephritis is supported by bone marrow transfer or kidney transplant studies in mice challenged with anti-GBM sera [ 88 – 90 ]. These studies have defined the roles of paper MHC-II, INF-?, and Fn14 expression on dissertation intrinsic renal cells in essay memory mediating nephritis. Overall, we have a very limited understanding of the role that intrinsic renal cells play in six sigma dissertation spontaneous lupus nephritis.
As discussed in this review, mouse models have proven to be indispensable for understanding the immunological and molecular basis of systemic autoimmunity in lupus. However, it is becoming increasingly clear that local autoimmunity in target organs and greek literature paper the responses that target organs play are equally important in disease pathogenesis. Murine models are also proving to be instrumental in helping us unravel the six sigma intricate mechanisms that underlie the end organ responses in lupus, although the specific roles of various cell types warrant systematic investigation. Mouse models have also enhanced our understanding of the college english respective roles of various cells and molecules in six sigma the innate immune system and the interplay between the innate and greek research adaptive immune systems in lupus pathogenesis. The challenge ahead is to dissertation better define the cellular and molecular players orchestrating lupus and to translate our improved understanding of essay about childhood memory lupus pathogenesis into better rationalized therapeutics targeting selected cells or molecules (or both) that facilitate lupus. Autoimmune Basis of Rheumatic Diseases. This article is part of six sigma dissertation a series on Systemic lupus erythematosus , edited by thesis, David Pisetsky, which can be found online at http://arthritis-research.com/series/lupus. This series forms part of a special collection of reviews covering major autoimmune rheumatic diseases, available at: http://arthritis-research.com/series/abrd. B-cell activation factor. glomerular basement membrane. New Zealand Black.
New Zealand White. plasmacytoid dendritic cell. systemic lupus erythematosus. tumor necrosis factor-alpha. Authors' original submitted files for images. The authors declare that they have no competing interests. Manderson AP, Botto M, Walport MJ: The role of six sigma dissertation complement in the development of systemic lupus erythematosus. Annu Rev Immunol.
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Ligue 1, Brest 0-1 Rennes : Termine ( 33e journee ) match Temps Forts Notes Resultats et Classement. Rennes repart victorieux pour la première fois de Francis-Le Blé grâce à un penalty bêtement offert par Brest. Six Sigma Dissertation. Les Rouge et Noir n'ont jamais été tranchants devant des locaux largement meilleurs en seconde période bien que maladroits devant le but. Trois minutes de temps additionnel sont annoncées. Grougi concède un coup franc à environ 35 mètres après une vilaine semelle sur un Rennais.
M'Vila s'élance. Essay On Problems. et voit son tir s'envoler très haut dans le ciel. La fatigue s'est emparée des vingt-deux acteurs. Six Sigma Dissertation. Rennes brûle ses dernières cartouches mais est bien muselé par la défense d'Alex Dupont. Au vu des débats, Brest risque de payer cher son manque de finition. System. Le Stade Brestois est toujours la plus mauvaise attaque de L1 (28 buts) et la 94ème sur 98 des 5 grands championnats européens. Le dernier changement du match : Féret est remplacé par Tettey côté Rennes. Féret croit pouvoir débloquer son équipe grâce à un coup franc très excentré à gauche. Dissertation. Le Rennais centre fort de l'intérieur du droit vers le second poteau mais Elana bondit pour attraper la sphère. Sur corner, Larsen Touré est servi et décroise trop sa tête ! Rennes a la tête sous l'eau et ne peut plus toucher le ballon sans commettre de faute. Près du point de corner gauche rennais, Grougi cisèle son coup franc enroulé du droit. Eclipse Of Community. Baysse est trop avancé et Costil sort dans les airs pour boxer le danger imminent ! Brest pousse fort dans la dernière ligne droite et monopolise la balle.
Rennes fait de plus en plus de fautes (Théophile-Catherine, Kana-Biyik). Alphonse déboule dans la surface depuis la gauche et pique sa balle au second poteau pour Zebina qui reprend du gauche en pivot ! Il faut un beau réflexe du pied de Costil pour détourner le ballon de la cage rennaise ! Lesoimier est remplacé par Mario Licka (Brest). Carton jaune pour Apam pour un tacle par derrière sur Poyet. Grougi essaie un contrôle périlleux entre Kana-Biyik et Apam mais finit par tomber aux pieds de Costil. Six Sigma. Dans la foulée, Lesoimier centre fort à ras de terre depuis la gauche, Costil, vigilant, capte le danger. Erding, fraîchement entré côté rennais, se distingue par de bons appels dans l'axe mais manque de ballons exploitables. A un quart d'heure du terme, les occasions sont toujours aussi rares. About Memory. Larsen Touré lâche un bon centre depuis la droite mais la balle roule jusqu'à l'autre aile. M'Vila joue un coup franc lointain excentré à gauche.
La transversale de l'international français est remis de la tête par Danzé vers Pitroipa. Dissertation. Le Burkinabé tente une reprise instinctive du droit qui finit par rouler tranquillement hors-cadre. Près du poteau de corner rennais gauche, Poyet centre en cloche vers Grougi dont la tête ne trouve que les gants de Costil, bien placé au milieu de son but. Brest garde plus la balle que Rennes (53 pour cent) mais baisse d'un cran en intensité après 25 minutes de bonne tenue. Féret emmène la balle à gauche, marqué par deux Brestois. Childhood. Le buteur rennais du jour adresse un bon centre au cordeau vers Erding au second poteau, mais l'ancien Parisien rate sa reprise de l'extérieur du gauche en tacle glissé. Hadji est remplacé par Erding (Rennes). Montaño laisse sa place à Boukari (Rennes).
Tandis que Brest va mieux, Rennes ne parvient toujours pas à élever son niveau de jeu. Et Ben Basat est remplacé par Poyet (Brest). Sur un coup franc excentré à droite de Grougi, Zebina smashe sa tête au second poteau mais rate le cadre de quelques centimètres ! C'est la meilleure occasion brestoise du match, les supporters risquent de s'en mordre les doigts. Ewolo est remplacé par Touré (Brest). Lesoimier est intenable à droite. Six Sigma Dissertation. Doumbia essaie de stopper le jeune Brestois mais ne réussit qu'à se voir punir d'un carton jaune. Ben Basat voit la balle lui tomber dans les pieds à trois mètres de Costil ! L'ailier brestois, surpris, ne réussit pas à frapper le cuir et s'en fait déposséder sur le champ. Doumbia s'érige devant Ben Basat et relance fort et loin. Literature Research Paper. A l'heure de jeu, Rennes fait le dos rond, sans que l'on sache vraiment si c'est une tactique d'Antonetti ou un réel regain de forme brestois. Bruno Grougi se fourvoie complètement et rate son centre du droit en pleine surface.
Lesoimier obtient un coup franc suite à une faute de Théophile-Catherine, à droite de la surface de Costil à 30 mètres. Ben Basat est très sollicité par ses partenaires dans tous les mouvements offensifs. Six Sigma. Ewolo tente de lui transmettre la balle mais sa passe est bien trop forte pour que l'Israélien ne la contrôle du bout du pied. Si l'imprécision est encore au rendez-vous, Brest s'applique à multiplier les passes et se montre clairement plus entreprenant. Grougi, balle au pied, s'en va provoquer Rennes dans sa surface et chute face à Apam qui laisse traîner ses crampons ! M. English Paper. Rainville ne déclare pas de penalty. Baysse et Alphonse se dédoublent à droite. Six Sigma Dissertation. Ce dernier adresse un centre tendu vers Grougi, dépassé par Kana-Biyik.
Ben Basat débarque à pleine vitesse de l'aile gauche, repique vers la surface mais tombe sous la pression de M'Vila. College English. Le Brestois réclame un penalty mais le duel épaule contre épaule était licite. Lesoimier, pas avare d'énergie, s'emmène la balle d'une jolie talonnade sur l'aile droite. Dissertation. Mais Théophile est plus rapide et s'empare du cuir, forçant le Brestois à commettre une petite poussette dans le dos de son vis-à-vis. Mais la tentative du Brestois sept fois buteur sur coup franc cette saison s'envole bien au-delà de la lucarne droite de Costil. Ben Basat obtient un coup franc intéressant dans l'axe aux 25 mètres grâce à Apam. Essay About Childhood. Grougi se met en place. Rennes relance le match à Francis-Le Blé. Six Sigma Dissertation. Face au défi physique des hommes d'Antonetti, Brest doit réagir et s'émanciper, poser son jeu de passes et percuter.
Rennes mène logiquement au score grâce au sang-froid de Féret sur penalty juste avant la pause. And Their Families. Mais l'avance semble très courte, tant les Rouge et Noir peinent à développer du jeu. Dissertation. La défense brestoise, très exposée, ne démérite pas dans le combat . But de Féret ! Le Rennais trompe Elana à contrepied sans trembler d'un plat du droit appliqué ! C'est son septième but en Ligue 1 cette saison, son deuxième sur penalty. Une minute de temps additionnel est annoncée. Pitroipa décroche un penalty pour un tirage de maillot commis par Kantari ! A l'approche de la pause, le jeu de Rennes s'est quelque peu délité à force de se reposer sur les coups de pied arrêtés octroyés par Brest. Essay With Behaviour. Lesoimier place un petit pont sur Théophile-Catherine, accélère mais pousse sa balle trop loin à droite. Grougi est pour le moment parfaitement neutralisé, toujours marqué par deux adversaires. Six Sigma. Culma, en cherchant à récupérer la balle dans les pieds de Montaño, reçoit un carton jaune. La partie se muscle de plus en plus. College English. C'est au tour du robuste Culma de subir une faute dans son dos de la part de Doumbia. Six Sigma. La frustration rennaise se fait palpable.
Carton jaune pour Théophile-Catherine pour son tacle en retard sur Ben Basat. A l'angle gauche de la surface de Costil, Alphonse s'infiltre par un crochet extérieur mais dévisse totalement sa frappe du droit. Of Community Thesis. Ben Basat évite le corner mais est repris virilement par Théophile-Catherine. Rennes a déjà tenté cinq tirs, contre un seul pour le Stade Brestois. M'Vila écope d'un carton jaune sur sa première faute de la partie. Six Sigma. Son tacle pied en avant sur la cheville d'Alphonse n'a pas plu à M. Essay On Problems. Rainville qui dégaine tout de suite l'avertissement. Daf prend un jaune pour un coup sur le tibia de Doumbia. A part les montées de Ben Basat, Brest reste désespérément stérile en attaque mais demeure solide en défense grâce à Baysse, Kantari et Culma. Dissertation. Rennes travaille sur les ailes mais se montre stéréotypé dans ses efforts. Dans l'axe, Ewolo cherche Ben Basat dans la profondeur en première intention mais l'Israélien est trop court pour battre Apam à la course.
Féret, très excentré à droite, joue le coup franc consécutif à la faute de Montaño et vise le second poteau. Our Education. Baysse lit bien la trajectoire du ballon et dégage de la tête. Pitroipa permute et provoque à droite, sans tromper Culma, dur sur l'homme. Dissertation. Montaño pêche par excès d'enthousiasme et tacle Ben Basat. Près de la ligne médiane, côté droit, Grougi joue un coup franc et alerte Alphonse devant lui. Essay With Behaviour. Lesoimier vient l'aider mais Rennes dégage en catastrophe. Sur le coup franc négocié par Féret, Kantari prend le meilleur dans les airs sur Hadji qui jaillissait dans son dos aux abords du point de penalty. Hadji dévie la balle d'une tête renversée dos au but vers la droite et Montaño. Six Sigma. Le Colombien progresse mais chute et obtient un coup franc très excentré à droite sous la pression de Daf.
Grougi transforme le coup franc obtenu à environ une trentaine de mètres dans l'axe. With Student Behaviour. Le milieu brestois frappe directement au but dans les gants de Costil qui touche là son premier ballon de la partie. Pitroipa prend un avertissement verbal pour avoir laissé traîner sa semelle sur le tibia de Ben Basat. Kantari, le stoppeur brestois, contient pour l'instant les efforts de Hadji. Six Sigma Dissertation. Les espaces sont restreints des deux côtés. English Paper. Ben Basat, à l'aise dans tout son couloir gauche, est précieux dans l'effort défensif. Lesoimier, dans l'axe, se décale un peu sur sa droite et tente une frappe écrasée du droit qui n'inquiète personne. Six Sigma. Grougi, à la limite du hors-jeu, attendait une offrande qu'il n'aura pas au final. Pitroipa, peu en vue dans ces 20 premières minutes, subit une charge de Lesoimier et obtient un coup franc, ce qui permet à son équipe de repartir de l'avant. Baysse défend en retard sur Hadji qui se débattait sur son aile gauche. Greek Literature. M. Dissertation. Rainville siffle une faute qui caractérise bien le problème de Brest : toujours un temps de retard.
Rennes mène dans le jeu et profite du déchet technique brestois. About Our Education. Les locaux sont inoffensifs en attaque et subissent les assauts répétés des Rouge et Noir dans ce premier quart d'heure. Kana-Biyik quitte sa ligne de défense, progresse dans l'axe, dribble deux Brestois et s'excentre un peu à gauche avant d'asséner un tir tendu du gauche en angle fermé. Six Sigma. Elana était bien placé à son poteau droit. Montaño prend de la vitesse dans l'axe et slalome avant de s'appuyer sur Hadji à droite en une-deux. Student Behaviour. La remise en première intention de son coéquipier est interceptée au vol. Nouveau corner rennais, même endroit, même tireur. Six Sigma Dissertation. Cette fois, Culma éloigne le danger de la tête. Féret se charge d'un corner côté gauche, dégagé par Baysse.
Montaño cherche la frappe de loin et obtient un nouveau corner. Le duel Montaño-Culma tourne déjà à plein régime. Military Families. Le Brestois se rend coupable d'une charge dans le dos du Rennais en plein saut. M'Vila récupère l'un des nombreux ballons perdus par Brest dans l'entrejeu, pique sa balle à gauche, sans effet. Six Sigma. Puis Ben Basat s'enfuit à gauche, réussit à servir Grougi dans l'axe mais le meneur est trop gêné pour armer sa frappe aux 20 mètres. Danzé profite de l'activité de Montaño pour monter dans son couloir et lâcher quelques centres. Greek Research. Dans la foulée, le Colombien perce à droite grâce à un contre favorable mais est rattrapé de justesse par la grinta de Culma. Rennes domine cette entame de rencontre en insistant sur l'aile gauche grâce à Pitroipa et Féret. Six Sigma. Sur un centre aérien, Baysse s'impose de la tête mais manque sa relance. English Paper. Montaño, à l'affût, ne parvient pas à caler son front. Depuis son retour dans l'élite, Brest n'a perdu que sept de ses trente-cinq derniers matches de L1 à Francis-Le Blé (16 nuls, 12 victoires.)
Hadji se procure la première occasion du match. Dissertation. Danzé adresse une transversale vers le Marocain qui part à la limite du hors-jeu pour défier Elana. With. La frappe croisée à ras de terre de l'attaquant est attrapée en deux temps par le portier brestois. La rencontre débute par une belle bataille au milieu de terrain. Dissertation. Rennes met en place son pressing et repousse Grougi dans l'axe qui cherchait l'ouverture idéale.
M. English. Nicolas Rainville est l'arbitre désigné pour la rencontre de ce soir. Six Sigma. Brest engage. Childhood. c'est parti ! Côté Brest, Larsen Touré réintègre le groupe après son opération pour pubalgie, comblant l'absence de Jemaa, suspendu. Six Sigma Dissertation. Chez les Rennais, Mangane est toujours blessé (cheville) et Brahimi, en balance avec Montaño pour l'aile droite, débutera sur le banc. Également organisé en 4-2-3-1, Rennes s'avance avec Costil dans la cage, derrière la défense Danzé (capitaine), Apam, Kana-Biyik et Théophile-Catherine. Military And Their Families. Doumbia et M'Vila ratisseront le milieu de terrain. Dissertation. Montaño, Féret et Pitroipa alimenteront Hadji. Devant Elana, Brest aligne un 4-2-3-1 avec Baysse, Zebina, Kantari et Daf en défense. Greek Research. Le capitaine Ewolo et Culma sont à la récupération. Six Sigma Dissertation. Lesoimier, Grougi et Ben Basat animeront le jeu offensif en soutien d'Alphonse en pointe. Il faut noter que Rennes n'a jamais gagné à Brest en L1 (2 nuls, 3 défaites).
En parallèle, les Rouge et Noir ont gagné huit de leurs déplacements cette saison, ce qui fait d'eux l'équipe la plus performante à l'extérieur, devant Lille et PSG (7 succès). En course pour une place européenne, Rennes affiche une forme contrastée sur ses six derniers matches de L1 (2 victoires, 2 nuls, 2 défaites). Families. Sans compter l'embarrassante déconvenue face à Quevilly en demi-finale de Coupe de France (1-2). Dans le sprint final du Championnat, Brest s'essouffle. Six Sigma. Les Bretons n'ont gagné qu'un seul de leurs six derniers matches (3-1 face à Lille le 7 avril dernier) et pointent aux portes de la zone rouge, à égalité de points avec Sochaux et Ajaccio.
Bonjour et bienvenue au stade Francis-Le Blé pour la 33ème journée de Ligue 1 2011/2012. Deployment And Their Families. Brest (17ème, 33 pts) reçoit Rennes (6ème, 51 pts).